Sunday’s Week 1 NFL schedule features a packed lineup of marquee matchups to kick off the 2025 season. Fans will see heavyweight clashes like the Steelers vs. Jets and divisional rivalry games like Seahawks vs. 49ers, Buccaneers vs. Falcons, Bengals vs. Browns, Giants vs. Commanders, and Lions vs. Packers. With such a loaded slate, daily Fantasy football players will need to dive deeper into NFL DFS player pool to find values for NFL DFS lineups. Should you target big name players like Bucky Irving, Malik Nabers, Tyreek Hill or George Kittle when making NFL DFS picks or building out you Week 1 NFL DFS strategy?
Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS Lineup Optimizer.
The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 1 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.
Top NFL Week 1 DFS picks for Sunday
One of the Optimizer’s top DFS value picks for Sunday is Commanders quarterback Jayden Daniels ($7,000 on DraftKings and $8,500 on FanDuel). Daniels took the NFL by storm as a rookie in 2024, throwing for 3,568 yards with 25 touchdowns and nine interceptions, while posting a 100.1 passer rating. He also added 891 rushing yards and 6 rushing touchdowns.
Daniels earned NFL Offensive Rookie of the Year honors, setting NFL rookie quarterback records in both completion percentage (69.0%) and rushing yards (891). He enters his second professional season with high expectations, and a relatively high fantasy floor. Daniels faces a New York Giants defense in Week 1 that was among the worst in the NFL in 2024. See who else to pick here.
The Optimizer’s NFL DFS strategy also includes rostering Packers running back Josh Jacobs ($6,700 on DraftKings and $7,800 on FanDuel), who has an over/under of 16.5 carries. Jacobs delivered a strong debut season with the Packers, rushing 301 times for 1,329 yards, while finding the end zone 15 times on the ground. He also added versatility as a receiver, catching 36 passes for 342 yards and scoring his first career receiving touchdown, making him a key dual-threat weapon for the Packers’ offense.
When healthy, Jacobs has proven to be one of the premier running backs in the NFL. His career body of work includes 6,874 rushing yards and 61 rushing touchdowns, and 233 catches for 1,790 yards and a score. Jacobs rushed for 161 yards and three touchdowns against the Lions, his Week 1 opponent, in 2024, and Detroit ranked just 22nd in yards per attempt allowed last season.. You can see the rest of the Optimizer’s NFL DFS picks here.
How to build Sunday Week 1 NFL DFS lineups
The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer’s NFL DFS picks, at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.
