Carse was ruled out for three months earlier this year because of serious cuts and blisters on his toes – an issue that first emerged on tours of Pakistan and New Zealand before Christmas.
Although he remained on the field in Birmingham, he was seen hobbling at various times when fielding and in his bowling follow-through.
Stokes, meanwhile, has returned to bowling this year following hamstring surgery.
He was seen stretching his groin on day one and, after a lengthy warm-up before play, opened the bowling on day two.
He delivered four overs for 16 runs but did not return to the attack in the remaining 58 overs of India’s innings. Similarly, Woakes did not feature after his four overs for 22 runs at the start of the day.
Off-spinner Shoaib Bashir bowled 45 overs for 3-167, Josh Tongue struggled as he took 2-119 from 28 overs and even Harry Brook bowled five overs of his part-time seam in their absence.
“India have batted great and with great control but the way England bowled today was a slight concern,” Vaughan said.
“There were a few things I saw in the field which made me think it was ominous going forward.”
