The Athletics will go for the three-game sweep when they battle the Tampa Bay Rays in a key American League matchup on Wednesday afternoon. The Athletics defeated Tampa Bay 6-4 on Monday and 4-3 on Tuesday. The Athletics (36-52), who are fifth in the AL West, are 21-25 on the road this year. The Rays (47-39), who have lost three in a row, are 27-25 on their home field in 2025.
First pitch from George M. Steinbrenner Field in Tampa, Fla., is set for 12:10 p.m. ET. The Athletics have won three of the last five meetings with the Rays. Tampa Bay is a -227 favorite on the money line (risk $227 to win $100) in the latest Rays vs. Athletics odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9. Before making any Athletics vs. Rays picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has set its sights on Athletics vs. Rays and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Athletics vs. Rays, which you can get in on with a DraftKings promo code or a FanDuel promo code.
Athletics vs. Rays money line |
Athletics +187, Tampa Bay -227 at DraftKings Sportsbook |
Athletics vs. Rays over/under |
9 runs |
Athletics vs. Rays run line |
Tampa Bay -1.5 (-115) |
Athletics vs. Rays picks |
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Athletics vs. Rays streaming |
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Why the Rays can win
Tampa Bay is expected to send right-hander Ryan Pepiot (5-6, 3.36 ERA) to the mound. In 17 starts this season, Pepiot has logged 96.1 innings, allowing 81 hits, 36 earned runs and 30 walks with 92 strikeouts. In an 8-3 win over the Detroit Tigers on June 21, he pitched five innings, allowing three hits, one earned run and two walks with seven strikeouts. He pitched eight innings in a 7-1 win over the Baltimore Orioles on June 16, allowing four hits, one earned run and two walks with 11 strikeouts.
Helping pace the Toronto offense is first baseman Jonathan Aranda. In 81 games this season, he is hitting .325 with 16 doubles, 10 homers and 45 RBI. He was 2-for-4 with an RBI in Monday’s loss to the Athletics. He was 2-for-5 with one homer and one RBI in a 22-8 loss to the Baltimore Orioles on Friday. See which team to back at SportsLine.
Why the Athletics can win
The Athletics are expected to start right-hander Mitch Spence (2-3, 3.82 ERA). He has appeared in 27 games, including five starts. In 63.2 innings pitched, he has allowed 62 hits, 27 earned runs and 21 walks with 55 strikeouts. In a 3-0 defeat to the New York Yankees on Friday, he took the loss, pitching five innings and allowing three hits, three runs – two earned – four walks with five strikeouts.
Shortstop Jacob Wilson is among the Athletics’ top offensive threats. In 81 games this season, he is hitting .339 with 16 doubles, nine homers, 40 RBI and five stolen bases. In Monday’s win, he was 2-for-5 with a double. He was 2-for-3 with a walk in an 11-4 loss at Detroit on June 24. See which team to back at SportsLine.
How to make Athletics vs. Rays picks
SportsLine’s model is leaning Over on the total, projecting 9.5 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins Rays vs. Athletics, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.