The Detroit Lions will look to turn around their fortunes after losing 27-13 to the NFC North rival Green Bay Packers in the season opener. The Lions can ill-afford to start off 0-2, especially against another division opponent. Detroit quarterback Jared Goff will also look to improve on his Week 1 numbers. In the loss to the Packers, Goff completed 31 of 39 passes for 225 yards and one touchdown with one interception and an 88.6 rating.
In a Super Bowl LIX rematch, the Philadelphia Eagles (-1.5) battle the Kansas City Chiefs in a key matchup with one of the slimmest margins of Week 2. Other tight NFL lines include Patriots vs. Dolphins (-1.5) and Buccaneers vs. Texans (-1.5). Which team has value to include in Week 2 NFL bets, and which side of the NFL odds should you target? Before locking in any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has scoured the Week 2 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of nearly 24-1. You can only see the model’s Week 2 NFL picks at SportsLine,
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Top Week 2 NFL picks
After simulating every game 10,000 times, the model is high on the Detroit Lions (-4.5, 47.5) to cover against the Chicago Bears. Detroit has won the NFC North in each of the past two seasons, including going 15-2 in 2024. The Lions are led by Goff, who is a 10-year veteran. In 17 games last season, Goff completed 72.4% of his passes for 4,629 yards and 37 touchdowns with 12 interceptions.
Among the many weapons the Lions offense features include tight end Sam LaPorta, who is among Detroit’s leading receivers. He caught six passes for 79 yards, including a long of 32 yards, in the loss to Green Bay. The Lions won both meetings last season, and the model has them covering in well over 60% of simulations in an A-rated pick. See which other NFL parlay picks to make here and bet the Lions to cover here:
How to make Week 2 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model’s Week 2 NFL best bets and NFL parlay at SportsLine.
What are the model’s top Week 2 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on an 33-17 run on top-rated picks, and find out.
